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  Depression causes There are several possible causes of depression. They can range from biological to circumstantial. Common causes  include : Brain chemistry.  There may be a chemical imbalance in parts of the brain that manage mood, thoughts, sleep, appetite, and behavior in people who have depression. Hormone levels.  Changes in female hormones  estrogen  and  progesterone  during different periods of time like during the  menstrual cycle ,  postpartum period , perimenopause, or  menopause  may all raise a person’s risk for depression. Family history.  You’re at a higher risk for developing depression if you have a family history of depression or another mood disorder. Early childhood trauma.  Some events affect the way your body reacts to fear and stressful situations. Brain structure.  There’s a greater risk for depression if the frontal lobe of your brain is less active. However, scientists don’t know if this happens before or after the onset of depressive symptoms. Medical cond